Multi-target chimaeric VLP as a therapeutic vaccine in a model of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination is a promising alternative to conventional treatment for colorectal cancer, using vaccines to induce targeted immune responses against tumour-associated antigens. In this study, we have developed chimaeric virus-like particles (VLP), a form of non-infectious non-replicative subunit vaccine consisting of rabbit haemorrhagic disease virus (RHDV) VP60 capsid proteins containing recombinantly inserted epitopes from murine topoisomerase IIα and survivin. These vaccines were developed in mono- (T.VP60, S.VP60) and multi-target (TS.VP60) forms, aiming to elucidate the potential benefits from multi-target vaccination.

Methods

Chimaeric RHDV VLP were developed by recombin

SUBMITTER: Donaldson B 

PROVIDER: S-EPMC5556368 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature