Proteomics informed by transcriptomics for characterising differential cellular susceptibility to Nelson Bay orthoreovirus infection.

ABSTRACT:

Background

Nelson Bay orthoreovirus (NBV) is a fusogenic bat borne virus with an unknown zoonotic potential. Previous studies have shown that NBV can infect and replicate in a wide variety of cell types derived from their natural host (bat), as well as from human, mouse and monkey. Within permissive cells, NBV induced significant cytopathic effects characterised by cell-cell fusion and syncytia formation. To understand the molecular events that underpin NBV infection we examined the host transcriptome and proteome response of two cell types, derived from bat (PaKiT03) and mouse (L929), to characterise differential cellular susceptibility to NBV.

Results

Despite significant differences in NBV replication and cytopathic effects in the L929 and PaKiT03 cells, the host response

SUBMITTER: Mok L 

PROVIDER: S-EPMC5556373 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature