Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles.

ABSTRACT: Extracellular vesicles (EVs), including microvesicles and exosomes, mediate intercellular signalling which has a profound role in cancer progression and in the development of metastasis. Internalisation of EVs can prompt functional changes in the recipient cells, the nature of which depends on the molecular composition and the cargo of the EVs. We hypothesised that the metastatic stage of cancerous parent cells would determine the uptake efficacy and the subsequent functional effects of the respective cancer cell-derived EVs. To address this question, we compared the internalisation of EVs derived from two metastatic site-derived prostate cancer cell lines (PC-3 and LNCaP), human telomerase reverse transcriptase immortalised primary malignant prostate epithelial cells (RC92a/hTERT), and a

SUBMITTER: Lazaro-Ibanez E 

PROVIDER: S-EPMC5556667 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature