The Diagnosis and Management of Alpha-1 Antitrypsin Deficiency in the Adult.

ABSTRACT: Background: The diagnosis and clinical management of adults with alpha-1 antitrypsin deficiency (AATD) have been the subject of ongoing debate, ever since the publication of the first American Thoracic Society guideline statement in 1989.¹ In 2003, the "American Thoracic Society (ATS)/European Respiratory Society (ERS) Statement: Standards for the Diagnosis and Management of Individuals with Alpha-1 Antitrypsin Deficiency" made a series of evidence-based recommendations, including a strong recommendation for broad-based diagnostic testing of all symptomatic adults with chronic obstructive pulmonary disease (COPD).² Even so, AATD remains widely under-recognized. To update the 2003 systematic review and clinical guidance, the Alpha-1 Foundation sponsored a commit

SUBMITTER: Sandhaus RA 

PROVIDER: S-EPMC5556762 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature