Comorbidity Distribution, Clinical Expression and Survival in COPD Patients with Different Body Mass Index.

ABSTRACT: Rationale: Contrary to the general population, in patients with chronic obstructive pulmonary disease (COPD) a low body mass index (BMI) is associated with excess mortality, while obesity appears protective (obesity paradox). We hypothesized that BMI is associated with a distinct number and expression of comorbidities in patients with COPD. The type of comorbidity may relate to mortality variability. Objectives and Methods: We followed 1659 COPD patients for a median of 51 months [IQR 27-77] with detailed comorbidity records and tracking pulmonary function, exercise capacity, dyspnea, health status, and cause of death. The cohort was categorized into the 5 National Heart Lung and Blood Institute (NHLBI) BMI groups with determination made about each group's relationship to spe

SUBMITTER: Divo MJ 

PROVIDER: S-EPMC5556867 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature