Correlation Between Emphysema and Lung Function in Healthy Smokers and Smokers With COPD.

ABSTRACT: Background: Emphysema is an important component of COPD; however, in previous studies of the correlation between airflow limitation (AFL) and computed tomography (CT) lung density as a surrogate for emphysema has varied. We hypothesised a good correlation between lung function (forced expiratory volume in first second [FEV₁]) and emphysema (15^th percentile density [PD15]) and that this correlation also exists between loss of lung tissue and decline in lung function even within the time frame of longitudinal studies of relatively short duration. Methods: We combined 2 large longitudinal studies (the Danish Lung Cancer Screening Trial [DLCST] and the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints [ECLIPSE]) of smokers or forme

SUBMITTER: Thomsen LH 

PROVIDER: S-EPMC5556883 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature