Perfluoroalkyl substances and beta cell deficient diabetes.

ABSTRACT:

Aims

Perfluoroalkyl substances (PFAS) are synthetic hydrocarbons shown to preserve pancreatic islet cell viability and reduce islet cell hypoxia and apoptosis. We investigated the relationship of serum PFAS with diabetes, and whether this varied by diabetes type.

Methods

6,460 individuals with and 60,439 without diabetes from the C8 Health Project, were categorized into three groups: type 1 (n=820), type 2 (n=4,291), or uncategorized diabetes (n=1,349, missing data on diabetes type or diabetes based on blood sugar at study entry). Four PFAS were investigated: perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononaoic acid (PFNA).

Results

PFAS levels were significantly lower in those with diabetes, and lowes

SUBMITTER: Conway B 

PROVIDER: S-EPMC5556924 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature