Short-Term Moderate Sleep Restriction Decreases Insulin Sensitivity in Young Healthy Adults.

ABSTRACT:

Context and purpose

The literature suggests that severe sleep loss of more than a few hours a night decreases glucose tolerance and insulin sensitivity. The aim of this study was to determine whether moderate sleep restriction had similar effects.

Methods

Fifteen healthy non-obese (BMI=24.5±3.4 kg/m²) young adults (20.6±1.3 years) completed two 2-hour oral glucose tolerance tests (OGTT): one was after 3 days of time-in-bed restriction by 1-3 hours each night, and the other was after 3 days of ad libitum sleep. Glucose and insulin concentrations during OGTT, and fasting glucagon and cortisol concentrations were determined. The homeostasis model of insulin resistance (HOMA-IR), Matsuda index, and the quantitative insulin sensitivity check index (QUICKI) were calcula

SUBMITTER: Wang X 

PROVIDER: S-EPMC5557027 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature