MRI assessment of whole-brain structural changes in aging.

ABSTRACT:

Purpose

One of the central features of brain aging is the accumulation of multiple age-related structural changes, which occur heterogeneously in individuals and can have immediate or potential clinical consequences. Each of these deficits can coexist and interact, producing both independent and additive impacts on brain health. Many of the changes can be visualized using MRI. To collectively assess whole-brain structural changes, the MRI-based Brain Atrophy and Lesion Index (BALI) has been developed. In this study, we validate this whole-brain health assessment approach using several clinical MRI examinations.

Materials and methods

Data came from three independent studies: the Alzheimer's Disease Neuroimaging Initiative Phase II (n=950; women =47.9%; age =72.7±7.4 years); t

SUBMITTER: Guo H 

PROVIDER: S-EPMC5557118 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature