Commutability and concordance of four hepatitis B virus DNA assays in an international multicenter study.

ABSTRACT:

Background

HBV DNA is the most important molecular marker in hepatitis B, used to determine treatment indication and monitoring. Most patients require lifelong hepatitis B virus (HBV) management, thus viral load (VL) monitoring may be performed at different laboratories, with different HBV assays, which may result in different VL results. This multicenter study compares the commutability and concordance of results from four different HBV DNA assays: CAP/CTM HBVv2, HPS/CTM HBVv2 and the new cobas 6800/8800 HBV and cobas 4800 HBV assays.

Methods

Across all four assays, HBV limit of detection (LoD) and linearity at lower concentrations were assessed using panels traceable to the World Health Organization international standard, and concordance was investigated at the important

SUBMITTER: Maasoumy B 

PROVIDER: S-EPMC5557192 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature