Multi-omics analysis provides insight to the Ignicoccus hospitalis-Nanoarchaeum equitans association.

ABSTRACT:

Background

Studies of interspecies interactions are inherently difficult due to the complex mechanisms which enable these relationships. A model system for studying interspecies interactions is the marine hyperthermophiles Ignicoccus hospitalis and Nanoarchaeum equitans. Recent independently-conducted 'omics' analyses have generated insights into the molecular factors modulating this association. However, significant questions remain about the nature of the interactions between these archaea.

Methods

We jointly analyzed multiple levels of omics datasets obtained from published, independent transcriptomics, proteomics, and metabolomics analyses. DAVID identified functionally-related groups enriched when I. hospitalis is grown alone or in co-culture with N. equitans. Enriched

SUBMITTER: Rawle RA 

PROVIDER: S-EPMC5557295 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature