How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.

ABSTRACT:

Purpose of review

An HIV-1 vaccine that elicits broadly neutralizing antibodies (bNAbs) remains to be developed. Here, we review how knowledge of bNAbs and HIV-1 entry mechanism is guiding the structure-based design of vaccine immunogens and immunization regimens.

Recent findings

Isolation of bNAbs from HIV-1-infected donors has led to an unprecedented understanding of the sites of vulnerability that these antibodies target on the HIV-1 envelope (Env) as well as of the immunological pathways that these antibody lineages follow to develop broad and potent neutralization. Sites of vulnerability, however, reside in the context of diverse Env conformations required for HIV-1 entry, including a prefusion-closed state, a single-CD4-bound intermediate, a three-CD4-bound intermediat

SUBMITTER: Pancera M 

PROVIDER: S-EPMC5557343 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature