Androgen receptor is expressed in mouse cardiomyocytes at prenatal and early postnatal developmental stages.

ABSTRACT:

Background

Previous studies show that androgens are involved in hypertrophy and excitability of cardiomyocytes and that their effects are mediated through their receptor. The aim of this study was to evaluate the presence of androgen receptor (AR) in mouse heart during prenatal and early postnatal stages.

Results

The expression of AR and related genes, alpha myosin heavy chain -Myh6-, beta myosin heavy chain -Myh7- and atrial natriuretic factor -Nppa- was simultaneously evaluated by semiquantitative RT-PCR. AR was also detected by immunohistochemistry. Androgen receptor mRNA was detected in hearts from 10.5 days post coitum to 16 postnatal days. A higher expression of AR mRNA in atria compared to ventricles was observed in neonatal mouse. A positive correlation between mRNA

SUBMITTER: Pedernera E 

PROVIDER: S-EPMC5557468 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature