Clinical and molecular surveillance of artemisinin resistant falciparum malaria in Myanmar (2009-2013).

ABSTRACT:

Background

Emergence of artemisinin-resistant malaria in Southeast Asian countries threatens the global control of malaria. Although K13 kelch propeller has been assessed for artemisinin resistance molecular marker, most of the mutations need to be validated. In this study, artemisinin resistance was assessed by clinical and molecular analysis, including k13 and recently reported markers, pfarps10, pffd and pfmdr2.

Methods

A prospective cohort study in 1160 uncomplicated falciparum patients was conducted after treatment with artemisinin-based combination therapy (ACT), in 6 sentinel sites in Myanmar from 2009 to 2013. Therapeutic efficacy of ACT was assessed by longitudinal follow ups. Molecular markers analysis was done on all available day 0 samples.

Results

True re

SUBMITTER: Nyunt MH 

PROVIDER: S-EPMC5557565 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature