Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase.

ABSTRACT: Heme is essential for respiration across all domains of life. However, heme accumulation can lead to toxicity if cells are unable to either degrade or export heme or its toxic by-products. Under aerobic conditions, heme degradation is performed by heme oxygenases, enzymes which utilize oxygen to cleave the tetrapyrrole ring of heme. The HO-1 family of heme oxygenases has been identified in both bacterial and eukaryotic cells, whereas the IsdG family has thus far been described only in bacteria. We identified a hypothetical protein in the eukaryotic green alga Chlamydomonas reinhardtii, which encodes a protein containing an antibiotic biosynthesis monooxygenase (ABM) domain consistent with those associated with IsdG family members. This protein, which we have named LFO1, degrades hem

SUBMITTER: Lojek LJ 

PROVIDER: S-EPMC5557675 | biostudies-literature | 2017 Jul-Aug

REPOSITORIES: biostudies-literature