White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging.

ABSTRACT: White matter tract integrity (WMTI) can characterize brain microstructure in areas with highly aligned fiber bundles. Several WMTI biomarkers have now been validated against microscopy and provided promising results in studies of brain development and aging, as well as in a number of brain disorders. Currently, WMTI is mostly used in dedicated animal studies and clinical studies of slowly progressing diseases, and has not yet emerged as a routine clinical tool. To this end, a less data intensive experimental method would be beneficial by enabling high resolution validation studies, and ease clinical applications by speeding up data acquisition compared with typical diffusion kurtosis imaging (DKI) protocols utilized as part of WMTI imaging. Here, we evaluate WMTI based on recently introduc

SUBMITTER: Hansen B 

PROVIDER: S-EPMC5557696 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature