Ontology highlight
ABSTRACT:
SUBMITTER: Scheel TKH
PROVIDER: S-EPMC5557892 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Scientific reports 20170815 1
With roles in development, cell proliferation and disease, micro-RNA (miRNA) biology is of great importance and a potential therapeutic target. Here we used cross-linking immunoprecipitation (CLIP) and ligation of miRNA-target chimeras on the Argonaute (AGO) protein to globally map miRNA interactions in the cow. The interactome is the deepest reported to date. miRNA targeting principles are consistent with observations in other species, but with expanded pairing rules. Experimental mapping robus ...[more]