Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis.

ABSTRACT: Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methylated CpGs and replicated them in two independent Danish cohorts. The double-replicated CpGs were characterized by distribution over gene regions and location in relation to CpG islands. The replicated CpGs were further characterized by involvement in biological pathways to study their functional implications in aging. We identified 67,604 age-associated CpG sites reaching genome-wide significance of FWER <0.05, 86% demethylated with increasing age. Double-replication resulted in 5,168 CpGs (39% age-methy

SUBMITTER: Li S 

PROVIDER: S-EPMC5557932 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature