Determining causal miRNAs and their signaling cascade in diseases using an influence diffusion model.

ABSTRACT: In recent studies, miRNAs have been found to be extremely influential in many of the essential biological processes. They exhibit a self-regulatory mechanism through which they act as positive/negative regulators of expression of genes and other miRNAs. This has direct implications in the regulation of various pathophysiological conditions, signaling pathways and different types of cancers. Studying miRNA-disease associations has been an extensive area of research; however deciphering miRNA-miRNA network regulatory patterns in several diseases remains a challenge. In this study, we use information diffusion theory to quantify the influence diffusion in a miRNA-miRNA regulation network across multiple disease categories. Our proposed methodology determines the critical disease specific miRN

SUBMITTER: Nalluri JJ 

PROVIDER: S-EPMC5557952 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature