EDGAR: a database of Disease-Gene Associations with annotated Relationships among genes.

ABSTRACT:

Background

Genetic investigations, boosted by modern sequencing techniques, allow dissecting the genetic component of different phenotypic traits. These efforts result in the compilation of lists of genes related to diseases and show that an increasing number of diseases is associated with multiple genes. Investigating functional relations among genes associated with the same disease contributes to highlighting molecular mechanisms of the pathogenesis.

Results

We present eDGAR, a database collecting and organizing the data on gene/disease associations as derived from OMIM, Humsavar and ClinVar. For each disease-associated gene, eDGAR collects information on its annotation. Specifically, for lists of genes, eDGAR provides information on: i) interactions retrieved from PDB, BI

SUBMITTER: Babbi G 

PROVIDER: S-EPMC5558190 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature