Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.

ABSTRACT: Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10^-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10^-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10^-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10^-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10^-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10^-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10^-10</

SUBMITTER: Melin BS 

PROVIDER: S-EPMC5558246 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature