Viral Retinopathy in Experimental Models of Zika Infection.

ABSTRACT:

Purpose

Emerging evidence has shown that both congenital and adult Zika virus (ZIKV) infection can cause eye diseases. The goals of the current study were to explore mechanisms and pathophysiology of ZIKV-induced eye defects.

Methods

Wild-type or A129 interferon type I receptor-deficient mice were infected by either FSS13025 or Mex1-7 strain of ZIKV. Retinal histopathology was measured at different time points after infection. The presence of viral RNA and protein in the retina was determined by in situ hybridization and immunofluorescence staining, respectively. Growth curves of ZIKV in permissive retinal cells were assessed in cultured retinal pigment epithelial (RPE) and Müller glial cells.

Results

ZIKV-infected mice developed a spectrum of ocular pathologies that

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC5558627 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature