Cord blood DNA methylation and adiposity measures in early and mid-childhood.

ABSTRACT:

Background

Excess adiposity in childhood is associated with numerous adverse health outcomes. As this condition is difficult to treat once present, identification of risk early in life can help inform and implement strategies to prevent the onset of the condition. We performed an epigenome-wide association study to prospectively investigate the relationship between cord blood DNA methylation and adiposity measurements in childhood.

Methods

We measured genome-wide DNA methylation from 478 children in cord blood and measured overall and central adiposity via skinfold caliper measurements in early (range 3.1-3.3 years) and mid-childhood (age range 7.3-8.3 years) and via dual X-ray absorptiometry (DXA) in mid-childhood. Final models were adjusted for maternal age at enrollment,

SUBMITTER: Kresovich JK 

PROVIDER: S-EPMC5558655 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature