LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures.

ABSTRACT:

Purpose

To describe clinical and electrographic characteristics of seizures LGI1-antibody encephalitis, and their correlations with two-year outcomes.

Methods

Video-electroencephalography recordings were performed on a cohort of 16 consecutive patients with LGI1-antibodies from two UK neuroscience-centers over five-years.

Results

From 14 of 16 patients (13 males; age-range 53-92years), 86 faciobrachial dystonic seizures were recorded at a median frequency of 0.4 per hour (range 0.1-9.8), and ictal EEG changes accompanied 5/86 events. In addition, 11/16 patients showed 53 other seizures - subclinical (n=18), motor (n=16), or sensory (n=19) - at a median of 0.1 per hour (range 0.1-2) associated with temporal and frontal discharges. The sensory events were most commonly

SUBMITTER: Aurangzeb S 

PROVIDER: S-EPMC5558811 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature