Factors associated with failure to achieve remission and with relapse after remission in patients with major depressive disorder in the PERFORM study.

ABSTRACT:

Background

The Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM) study has been initiated to better understand the course of a depressive episode and its impact on patient functioning. This analysis aimed to identify sociodemographic and clinical factors associated with failure to achieve remission at month 2 after initiating or switching antidepressant monotherapy and with subsequent relapse at month 6 for patients in remission at month 2.

Materials and methods

This was a 2-year observational cohort study in 1,159 outpatients aged 18-65 years with major depressive disorder initiating or undergoing the first switch of antidepressant monotherapy. Factors with P<0.20 in univariate logistic regression analyses wer

SUBMITTER: Saragoussi D 

PROVIDER: S-EPMC5558880 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature