N⁶-methyladenosine is required for the hypoxic stabilization of specific mRNAs.

ABSTRACT: Post-transcriptional regulation of mRNA during oxygen deprivation, or hypoxia, can affect the survivability of cells. Hypoxia has been shown to increase stability of a subset of ischemia-related mRNAs, including VEGF. RNA binding proteins and miRNAs have been identified as important for post-transcriptional regulation of individual mRNAs, but corresponding mechanisms that regulate global stability are not well understood. Recently, mRNA modification by N⁶-methyladenosine (m⁶A) has been shown to be involved in post-transcriptional regulation processes including mRNA stability and promotion of translation, but the role of m⁶A in the hypoxia response is unknown. In this study, we investigate the effect of hypoxia on RNA modifications including m^6</

SUBMITTER: Fry NJ 

PROVIDER: S-EPMC5558913 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature