Mechanisms for pattern specificity of deep-brain stimulation in Parkinson's disease.

ABSTRACT: Deep brain stimulation (DBS) has become a widely used technique for treating advanced stages of neurological and psychiatric illness. In the case of motor disorders related to basal ganglia (BG) dysfunction, several mechanisms of action for the DBS therapy have been identified which might be involved simultaneously or in sequence. However, the identification of a common key mechanism underlying the clinical relevant DBS configurations has remained elusive due to the inherent complexity related to the interaction between the electrical stimulation and the neural tissue, and the intricate circuital structure of the BG-thalamocortical network. In this work, it is shown that the clinically relevant range for both, the frequency and intensity of the electrical stimulation pattern, is an emergen

SUBMITTER: Velarde OM 

PROVIDER: S-EPMC5558964 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature