Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness.

ABSTRACT: General anesthesia (GA) is a reversible drug-induced state of altered arousal required for more than 60,000 surgical procedures each day in the United States alone. Sedation and unconsciousness under GA are associated with stereotyped electrophysiological oscillations that are thought to reflect profound disruptions of activity in neuronal circuits that mediate awareness and cognition. Computational models make specific predictions about the role of the cortex and thalamus in these oscillations. In this paper, we provide in vivo evidence in rats that alpha oscillations (10-15 Hz) induced by the commonly used anesthetic drug propofol are synchronized between the thalamus and the medial prefrontal cortex. We also show that at deep levels of unconsciousness where movement ceases, coherent tha

SUBMITTER: Flores FJ 

PROVIDER: S-EPMC5558998 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature