Mapping of human brown adipose tissue in lean and obese young men.

ABSTRACT: Human brown adipose tissue (BAT) can be activated to increase glucose uptake and energy expenditure, making it a potential target for treating obesity and metabolic disease. Data on the functional and anatomic characteristics of BAT are limited, however. In 20 healthy young men [12 lean, mean body mass index (BMI) 23.2 ± 1.9 kg/m²; 8 obese, BMI 34.8 ± 3.3 kg/m²] after 5 h of tolerable cold exposure, we measured BAT volume and activity by ¹⁸F-labeled fluorodeoxyglucose positron emission tomography/computerized tomography (PET/CT). Obese men had less activated BAT than lean men (mean, 130 vs. 334 mL) but more fat in BAT-containing depots (mean, 1,646 vs. 855 mL) with a wide range (0.1-71%) in the ratio of activated BAT to inactive fat between individuals. Six

SUBMITTER: Leitner BP 

PROVIDER: S-EPMC5559032 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature