Comprehensive comparison of neonate and adult human platelet transcriptomes.

ABSTRACT: Understanding the underlying mechanisms of the well-substantiated platelet hyporeactivity in neonates is of interest given their implications for the clinical management of newborns, a population at higher bleeding risk than adults (especially sick and preterm infants), as well as for gaining insight into the regulatory mechanisms of platelet biology. Transcriptome analysis is useful in identifying mRNA signatures affecting platelet function. However, human fetal/neonatal platelet transcriptome analysis has never before been reported. We have used mRNA expression array for the first time to compare platelet transcriptome changes during development. Microarray analysis was performed in pure platelet RNA obtained from adult and cord blood, using the same platform in two independent laborator

SUBMITTER: Caparros-Perez E 

PROVIDER: S-EPMC5559076 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature