Chronic Obstructive Pulmonary Disease Genetics: A Review of the Past and a Look Into the Future.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) affects over 10 million Americans.¹ This complex disorder demonstrates many different presentations in a wide variety of patients, and results from a combination of environmental exposures and genetic risk factors. Smoking alone does not result in COPD: not all smokers develop COPD and lung function decline among smokers is highly variable. There is growing evidence for genetic risk factors for COPD: early familial aggregation and linkage analysis studies strongly suggested genetic contributions to COPD, and recent genome-wide association studies have identified several genomic regions that are clearly related to COPD susceptibility. However, despite recent advances in COPD genetics, much of the heritability of COPD remains unexplaine

SUBMITTER: Hardin M 

PROVIDER: S-EPMC5559139 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature