Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication.

ABSTRACT:

Background

Prevalence estimates of the serious hazards of transfusion vary widely. We hypothesized that the current reporting infrastructure in the United States fails to capture many transfusion reactions and undertook a multicenter study using active surveillance, data review, and adjudication to test this hypothesis.

Study design and methods

A retrospective record review was completed for a random sample of 17% of all inpatient transfusion episodes over 6 months at four academic tertiary care hospitals, with an episode defined as all blood products released to a patient in 6 hours. Data were recorded by trained clinical research nurses, and serious reactions were adjudicated by a panel of transfusion medicine experts.

Results

Of 4857 transfusion episodes investigat

SUBMITTER: Hendrickson JE 

PROVIDER: S-EPMC5559198 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature