Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart.

ABSTRACT:

Rationale

The transcription factor Islet-1 is a marker of cardiovascular progenitors during embryogenesis. The isolation of Islet-1-positive (Islet-1(+)) cells from early postnatal hearts suggested that Islet-1 also marks cardiac progenitors in adult life.

Objective

We investigated the distribution and identity of Islet-1(+) cells in adult murine heart and evaluated whether their number or distribution change with age or after myocardial infarction.

Methods and results

Distribution of Islet-1(+) cells in adult heart was investigated using gene targeted mice with nuclear β-galactosidase inserted into the Islet-1 locus. nLacZ-positive cells were only present in 3 regions of the adult heart: clusters in the interatrial septum and around the pulmonary veins, scattered wit

SUBMITTER: Weinberger F 

PROVIDER: S-EPMC5559221 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature