Increased HIV-1 superinfection risk in carriers of specific human leukocyte antigen alleles.

ABSTRACT:

Objective

The aim of this study was to characterize the demographic, behavioural, clinical and immunogenetic determinants of HIV-1 superinfection in a high-risk cohort of MSM.

Design

A retrospective cohort study of prospectively followed MSM.

Methods

Ninety-eight MSM with acute or early HIV-1 monoinfection were followed for a median of 15.6 months. Demographic and human leukocyte antigen (HLA) genotype data were collected at enrolment. Sexual behaviour, clinical and the infection status (monoinfection or superinfection) data were recorded at each visit (at enrolment and thereafter at a median of 4.2-month intervals). HIV-1 superinfection risk was determined by Cox regression and Kaplan-Meier survival analysis.

Results

Ten individuals (10.2%) had superinfection

SUBMITTER: Vesa J 

PROVIDER: S-EPMC5559224 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature