Standard vaccines increase HIV-1 transcription during antiretroviral therapy.

ABSTRACT:

Objectives

Curative strategies using agents to perturb the HIV reservoir have demonstrated only modest activity, whereas increases in viremia after standard vaccination have been described. We investigated whether vaccination against non-HIV pathogens can induce HIV transcription and thereby play a role in future eradication strategies.

Design

A randomized controlled trial (NCT00329251) was performed to compare the effects of clinical vaccines with placebo on HIV transcription and immune activation.

Methods

Twenty-six HIV-infected individuals on suppressive antiretroviral therapy were randomized to receive a vaccination schedule (n = 13) or placebo (n = 13). Cell-associated RNA and DNA were extracted from peripheral blood mononuclear cells, and HIV was quantified by d

SUBMITTER: Yek C 

PROVIDER: S-EPMC5559226 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature