Gene fusions and gene duplications: relevance to genomic annotation and functional analysis.

ABSTRACT:

Background

Escherichia coli a model organism provides information for annotation of other genomes. Our analysis of its genome has shown that proteins encoded by fused genes need special attention. Such composite (multimodular) proteins consist of two or more components (modules) encoding distinct functions. Multimodular proteins have been found to complicate both annotation and generation of sequence similar groups. Previous work overstated the number of multimodular proteins in E. coli. This work corrects the identification of modules by including sequence information from proteins in 50 sequenced microbial genomes.

Results

Multimodular E. coli K-12 proteins were identified from sequence similarities between their component modules and non-fused proteins in 50 genomes and f

SUBMITTER: Serres MH 

PROVIDER: S-EPMC555942 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature