Identification of putative noncoding polyadenylated transcripts in Drosophila melanogaster.

ABSTRACT: Analysis of EST and cDNA collections from a number of metazoan species has identified genes encoding long polyadenylated transcripts that do not contain ORFs of lengths typical for protein-encoding mRNAs. Noncoding functions of such polyadenylated transcripts have been elucidated in only a few examples. The corresponding genes neither contain hallmark sequence motifs nor appear to have been conserved across phyla. Thus, it is impossible to systematically identify new members of this class of gene by using sequence homology and traditional gene-finding algorithms that depend on protein-coding potential. Consequently, even their approximate number has not been established for any metazoan genome. We curated polyadenylated transcripts with limited protein-coding capacity from intergenic regio

SUBMITTER: Tupy JL 

PROVIDER: S-EPMC555963 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature