Altered microstructure in temporal lobe epilepsy: a diffusional kurtosis imaging study.

ABSTRACT:

Background and purpose

Temporal lobe epilepsy is associated with regional abnormalities in tissue microstructure, as demonstrated by DTI. However, the full extent of these abnormalities has not yet been defined because DTI conveys only a fraction of the information potentially accessible with diffusion MR imaging. In this study, we assessed the added value of diffusional kurtosis imaging, an extension of DTI, to evaluate microstructural abnormalities in patients with temporal lobe epilepsy.

Materials and methods

Thirty-two patients with left temporal lobe epilepsy and 36 matched healthy subjects underwent diffusion MR imaging. To evaluate abnormalities in patients, we performed voxelwise analyses, assessing DTI-derived mean diffusivity, fractional anisotropy, and diffusional

SUBMITTER: Bonilha L 

PROVIDER: S-EPMC5559661 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature