Learning a Comorbidity-Driven Taxonomy of Pediatric Pulmonary Hypertension.

ABSTRACT:

Rationale

Pediatric pulmonary hypertension (PH) is a heterogeneous condition with varying natural history and therapeutic response. Precise classification of PH subtypes is, therefore, crucial for individualizing care. However, gaps remain in our understanding of the spectrum of PH in children.

Objective

We seek to study the manifestations of PH in children and to assess the feasibility of applying a network-based approach to discern disease subtypes from comorbidity data recorded in longitudinal data sets.

Methods and results

A retrospective cohort study comprising 6 943 263 children (<18 years of age) enrolled in a commercial health insurance plan in the United States, between January 2010 and May 2013. A total of 1583 (0.02%) children met the criteria for PH. We id

SUBMITTER: Ong MS 

PROVIDER: S-EPMC5559726 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature