Xenopus as a model system to study transcriptional regulatory networks.

ABSTRACT: Development is controlled by a complex series of events requiring sequential gene activation. Understanding the logic of gene networks during development is necessary for a complete understanding of how genes contribute to phenotype. Pioneering work initiated in the sea urchin and Drosophila has demonstrated that reasonable transcriptional regulatory network diagrams representing early development in multicellular animals can be generated through use of appropriate genomic, genetic, and biochemical tools. Establishment of similar regulatory network diagrams for vertebrate development is a necessary step. The amphibian Xenopus has long been used as a model for vertebrate early development and has contributed greatly to the elucidation of gene regulation. Because the best and most extensivel

SUBMITTER: Koide T 

PROVIDER: S-EPMC555977 | biostudies-literature | 2005 Apr

REPOSITORIES: biostudies-literature