Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration.

ABSTRACT:

Background

Hair cell loss in the cochlea is caused by ototoxic drugs, aging, and environmental stresses and could potentially lead to devastating pathophysiological effects. In adult mammals, hair cell loss is irreversible and may result in hearing and balance deficits. In contrast, nonmammalian vertebrates, including birds, can regenerate hair cells through differentiation of supporting cells and restore inner ear function, suggesting that hair cell progenitors are present in the population of supporting cells.

Results

In the present study, we aimed to identify novel genes related to regeneration in the chicken utricle by gene expression profiling of supporting cell and hair cell populations obtained by laser capture microdissection. The volcano plot identified 408 differen

SUBMITTER: Wakasaki T 

PROVIDER: S-EPMC5559865 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature