The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats.

ABSTRACT: Manganese is an essential dietary nutrient and trace element with important roles in mammalian development, metabolism, and antioxidant defense. In healthy individuals, gastrointestinal absorption and hepatobiliary excretion are tightly regulated to maintain systemic manganese concentrations at physiologic levels. Interactions of manganese with other essential metals following high dose ingestion are incompletely understood. We previously reported that gavage manganese exposure in rats resulted in higher tissue manganese concentrations when compared with equivalent dietary or drinking water manganese exposures. In this study, we performed follow-up evaluations to determine whether oral manganese exposure perturbs iron, copper, or zinc tissue concentrations. Rats were exposed to a control d

SUBMITTER: Mercadante CJ 

PROVIDER: S-EPMC5560020 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature