Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi.

ABSTRACT:

Background

Platelet cross-linking during arterial thrombosis involves von Willebrand Factor (VWF) multimers. Therefore, proteolysis of VWF appears promising to disaggregate platelet-rich thrombi and restore vessel patency in acute thrombotic disorders such as ischemic stroke, acute coronary syndrome, or acute limb ischemia. N-Acetylcysteine (NAC, a clinically approved mucolytic drug) can reduce intrachain disulfide bonds in large polymeric proteins. In the present study, we postulated that NAC might cleave the VWF multimers inside occlusive thrombi, thereby leading to their dissolution and arterial recanalization.

Methods

Experimental models of thrombotic stroke induced by either intra-arterial thrombin injection or ferric chloride application followed by measurement

SUBMITTER: Martinez de Lizarrondo S 

PROVIDER: S-EPMC5560034 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature