Dataset Information
Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection.
Ontology highlight
ABSTRACT: Background
Understanding natural HIV control may lead to new preventative or therapeutic strategies. Several protective major histocompatibility complex (MHC) genotypes were found in humans and rhesus macaques. Here, we report a simian immunodeficiency virus (SIV) controller MHC genotype in Mauritian cynomolgus macaques (MCMs).Methods
Twelve MHC-genotyped MCMs were infected with SIVmac251 and monitored for viral loads and CD4+ T-cell counts.Results
Two macaques with M3M4 genotype exhibited the lowest peak viral loads (log plasma SIV RNA copies/mL), nearly 3 logs lower than those in most macaques with other MHC haplotype combinations, and set point viral loads below the level of detection limit by RT-qPCR (<2 log RNA copies/mL). They maintained healthy CD4+ T-cell counts of >500 cells/μL blood, while CD4 counts in the vast majority of other macaques were below this level.Conclusions
The M3M4 MHC genotype may confer enhanced control of SIV replication in MCMs.
SUBMITTER: Li H
PROVIDER: S-EPMC5560087 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Publications
Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection.
Journal of medical primatology 20170801 4
<h4>Background</h4>Understanding natural HIV control may lead to new preventative or therapeutic strategies. Several protective major histocompatibility complex (MHC) genotypes were found in humans and rhesus macaques. Here, we report a simian immunodeficiency virus (SIV) controller MHC genotype in Mauritian cynomolgus macaques (MCMs).<h4>Methods</h4>Twelve MHC-genotyped MCMs were infected with SIVmac251 and monitored for viral loads and CD4+ T-cell counts.<h4>Results</h4>Two macaques with M3M4 ...[more]
