Failure patterns after hemithoracic pleural intensity modulated radiation therapy for malignant pleural mesothelioma.

ABSTRACT:

Purpose

We previously reported our technique for delivering intensity modulated radiation therapy (IMRT) to the entire pleura while attempting to spare the lung in patients with malignant pleural mesothelioma (MPM). Herein, we report a detailed pattern-of-failure analysis in patients with MPM who were unresectable or underwent pleurectomy/decortication (P/D), uniformly treated with hemithoracic pleural IMRT.

Methods and materials

Sixty-seven patients with MPM were treated with definitive or adjuvant hemithoracic pleural IMRT between November 2004 and May 2013. Pretreatment imaging, treatment plans, and posttreatment imaging were retrospectively reviewed to determine failure location(s). Failures were categorized as in-field (within the 90% isodose line), marginal (<90% and ≥

SUBMITTER: Rimner A 

PROVIDER: S-EPMC5560169 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature