Does substance use compromise depression treatment in persons with HIV? Findings from a randomized controlled trial.

ABSTRACT: Depression and substance use are significant obstacles to effective HIV care. Using data derived from a randomized controlled trial of persons with HIV who are homeless or marginally housed, this study assesses the utility of antidepressant treatment among persons with HIV, depression, and active substance use. Participants were diagnosed with depressive disorders and randomly assigned to receive directly observed therapy with fluoxetine or a referral to community mental health treatment. Assessments, conducted at baseline and every 3 months over a 9-month period, included the Hamilton Rating Scale for Depression, the Beck Depression Inventory II, and self-report of alcohol, crack, cocaine, heroin, or methamphetamine use in the past 90 days. To investigate the effect of antidepressant trea

SUBMITTER: Grelotti DJ 

PROVIDER: S-EPMC5560264 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature