Neural - hormonal responses to negative affective stimuli: Impact of dysphoric mood and sex.

ABSTRACT:

Background

Maladaptive responses to negative affective stimuli are pervasive, including clinically ill and healthy people, and men and women respond differently at neural and hormonal levels. Inspired by the Research Domain Criteria initiative, we used a transdiagnostic approach to investigate the impact of sex and dysphoric mood on neural-hormonal responses to negative affective stimuli.

Methods

Participants included 99 individuals with major depressive disorder, psychosis and healthy controls. Functional magnetic resonance imaging (fMRI) was complemented with real-time acquisition of hypothalamo-pituitary-adrenal (HPA) and -gonadal (HPG) hormones. fMRI data were analyzed in SPM8 and task-related connectivity was assessed using generalized psychophysiological interaction.

SUBMITTER: Mareckova K 

PROVIDER: S-EPMC5560420 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature