Population activity structure of excitatory and inhibitory neurons.

ABSTRACT: Many studies use population analysis approaches, such as dimensionality reduction, to characterize the activity of large groups of neurons. To date, these methods have treated each neuron equally, without taking into account whether neurons are excitatory or inhibitory. We studied population activity structure as a function of neuron type by applying factor analysis to spontaneous activity from spiking networks with balanced excitation and inhibition. Throughout the study, we characterized population activity structure by measuring its dimensionality and the percentage of overall activity variance that is shared among neurons. First, by sampling only excitatory or only inhibitory neurons, we found that the activity structures of these two populations in balanced networks are measurably dif

SUBMITTER: Bittner SR 

PROVIDER: S-EPMC5560553 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature