GTSP1 expression in non-smoker and non-drinker patients with squamous cell carcinoma of the head and neck.

ABSTRACT:

Introduction

The main risk factors for head and neck squamous cell carcinoma (HNSCC) are tobacco and alcohol consumption and human papillomavirus (HPV) infection. However, in a subset of patients, no risk factors can be identified. Glutathione S-transferase π (GTSP1) is a carcinogen-detoxifying enzyme that is activated by exposure to carcinogens, and it is associated with a reduction in response to toxic therapies. We studied the expression of GTSP1 in tumor and non-tumor tissue samples from patients with and without these risks to identify whether GTSP1 expression differs according to exposure to carcinogens.

Materials and methods

Non-smoker/non-drinker (NSND) and smoker/drinker (SD) patients were matched according to age, gender, tumor site, TNM stage, grade and histologic

SUBMITTER: Soares PO 

PROVIDER: S-EPMC5560606 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature