SnoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma.

ABSTRACT: Lung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Therefore, it is possible that these two groups present differences besides the smoking status, including differences in their gene expression signature. The altered expression patterns of non-coding RNAs in complex diseases make them potential biomarkers for diagnosis and treatment. We analyzed data from differentially and constitutively expressed PIWI-interacting RNAs and small nucleolar RNAs from publicly available small RNA high-throughput sequencing data in search of an expression pattern of non-

SUBMITTER: Nogueira Jorge NA 

PROVIDER: S-EPMC5560661 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature